Overview

In chemoenzymatic synthesis biocatalytic methods and contemporary organic methods are synergistically combined towards a multistep or one-pot process. This strategy allows to benefit of the exceptional regio- and stereo-selectivity of enzymatic transformations, while also taking advantage of the variety of organic reactions to create chemical bonds which are unattainable using purely enzymatic or organic means. Therefore, chemoenzymatic strategies hold enormous potential for accessing valuable building blocks, natural products and bioactive molecules. Moreover, particularly chemoenzymatic one-pot processes represent an attractive synthetic concept for the improvement of overall process efficiency by decreasing the required number of work up and purification steps. Due to avoidance of such time-, capacity- and solvent-intensive process steps, one-pot syntheses contribute to a significantly improved process economy as well as to more sustainable procedure.